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目的通过动物实验探讨二硝酸异山梨醇酯（Ｉｓｏｋｅｔ）介入９９ｍＴｃ－ＭＩＢＩ显像在心肌存活力估测中的价值。方法用结扎左冠状动脉前降支的方法制成９只犬心肌梗死模型，随机分为三组（Ⅰ、Ⅱ、Ⅲ组）分别于冠状动脉结扎１．５ｈ、３．０ｈ、６．０ｈ再灌注。对９只犬心肌梗死再灌注模型进行静息９９ｍＴｃ－ＭＩＢＩ、Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ心肌断层显像。结果３组犬在静息心肌显像中的１９、２３、２５个放射性分布异常节段各有１０个节段出现放射性填充，分别占５２．６％、４３．３％、４０．０％，Ｉｓｏｋｅｔ介入后，三组犬的放射分布得分亦降低。结论Ｉｓｏｋｅｔ能明显提高９９ｍＴｃ－ＭＩＢＩ对心肌存活力的估计，Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ显像是评估心肌存活力的实用方法。
Objective To investigate the value of Isoket-mediated 99m Tc-MIBI imaging in the estimation of myocardial viability in animal experiments. Methods Nine dogs with myocardial infarction were established by ligation of left anterior descending coronary artery. They were randomly divided into three groups (Ⅰ, Ⅱ and Ⅲ). The coronary arteries were ligated for 1.5h, 3.0h and 6.0h perfusion. Resting 99mTc-MIBI was performed on 9 dogs with myocardial infarction reperfusion and Isoket interventional 99mTc-MIBI myocardial perfusion imaging. Results In the rest myocardial infarction group, there were 10 segments of 19, 23 and 25 radioactive segments with radioactive filling in each group, accounting for 52.6%, 43.3% and 40.0% respectively, After Isoket intervention, the radiation distribution scores of the three groups of dogs also decreased. Conclusions Isoket can significantly improve the estimation of myocardial viability using 99mTc-MIBI. Isoket interventional 99mTc-MIBI imaging is a useful method to assess myocardial viability.