羊膜穿刺及免疫分析的发展,对于人们了解健康及患病胎儿内分泌腺的功能帮助颇大。本文对围产期内分泌学中的两个方面即先天性营养不良性甲状腺功能低下及先天性肾上腺皮质增生进行了讨论。先天性甲状腺功能低下(简称先天性甲低) 甲状腺系由内胚叶的内分泌组织发育而来。在妊娠第7周已达其固定的位置,甲状舌管开始了正常的萎缩。至第10周可以浓集碘,到第12周能将碘酪氨酸偶联成三碘甲状腺原氨 The development of amniocentesis and immunoassay is of great help in understanding the function of endocrine glands in healthy and diseased fetuses. This article discusses two aspects of perinatal endocrinology, namely, congenital malnutrition hypothyroidism and congenital adrenal hyperplasia. Congenital hypothyroidism (referred to as congenital hypothyroidism) thyroid from endocrine endocrine tissue development. In the seventh week of pregnancy has reached its fixed position, thyroglossal tongue began normal atrophy. Iodine can be concentrated by week 10, and iodotyrosine can be coupled to triiodothyronine by week 12