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目的观察尼麦角林在老年慢性脑血管功能不全中的应用效果。方法 112例老年慢性脑血管功能不全患者,采取数字随机法分成观察组和对照组,各56例。对照组采取常规治疗,观察组在对照组基础上采取尼麦角林治疗,比较两组临床效果。结果观察组总有效率96.43%高于对照组80.36%,差异有统计学意义(P<0.05)。两组治疗12周后的收缩期峰流速(Vs)、舒张期末流速(Vd)、搏动指数(PI)、阻力指数(RI)水平均优于本组治疗前,且观察组优于对照组,差异均有统计学意义(P<0.05)。两组治疗后的简易精神状态评价量表(MMSE)评分均高于本组治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生不良反应。结论尼麦角林可有效的改善老年慢性脑血管功能不全患者各项指标,提高治疗总有效率,是一种有效的治疗药物。
Objective To observe the effect of nicergoline on senile chronic cerebrovascular insufficiency. Methods 112 elderly patients with chronic cerebrovascular insufficiency were randomly divided into observation group and control group with 56 cases in each group. The control group to take conventional treatment, the observation group on the basis of the control group to take nicergoline treatment, the clinical effect of two groups were compared. Results The total effective rate of observation group was 96.43% higher than that of control group (80.36%), the difference was statistically significant (P <0.05). The peak systolic velocity (Vs), end diastolic velocity (Vd), pulsatility index (PI) and resistance index (RI) of the two groups after 12 weeks of treatment were better than those before treatment in the two groups and the observation group was superior to the control group The differences were statistically significant (P <0.05). MMSE scores of the two groups after treatment were higher than those before treatment, and the observation group was higher than the control group, the difference was statistically significant (P <0.05). No adverse reactions occurred in both groups. Conclusion Nicergoline can effectively improve the indicators of elderly patients with chronic cerebrovascular insufficiency and improve the total effective rate, which is an effective therapeutic drug.