论文部分内容阅读
据报道约有2～15%的破伤风患者曾接受全程初免,说明复种的必要。但初种后隔多长时间复种,意见尚不一致。作者采用随机选择和整群抽样方法选择不同性别和年龄的观察对象637人,他们是经过初种而未行复种以及接种史(包括复种史)清楚的儿童和成人。复种皮下注射吸附破伤风类毒素6Lf或12Lf,注射后4周取静脉血,用ELISA检测,其中抗毒素含量<0.2IU/ml者再作体内中和试验。对结果进行横断面与纵向性分析并采用回归统计方法。结果表明:初种后第1年抗体下降较快,两年后血清破伤风抗毒素浓度与时间关系呈指数下降。复种后血清抗毒素浓度与时间关系取决于复种年龄及初、复种
It has been reported that about 2 ~ 15% of patients with tetanus have received full initial immunization, indicating the need for multiple cropping. However, how long after the first seed multiplication, the opinion is not consistent. The authors selected 637 people of different sexes and ages using random selection and cluster sampling methods. They were children and adults who had been first-born without multiple cropping and had a clear history of vaccination (including multiple seeding history). Subcutaneous injection of tetanus toxoid 6Lf or 12Lf by subcutaneous injection, 4 weeks after the injection of venous blood, with ELISA test, in which the antitoxin content of <0.2IU / ml were in-vivo neutralization test. The results of cross-sectional and longitudinal analysis and regression statistical methods. The results showed that the first year after the first antibody decreased rapidly, two years later the serum tetanus antitoxin concentration showed an exponential decline. The level of serum antitoxin after the multiple cropping depends on the age of the multiple cropping and the initial and multiple cropping