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孕鼠及新生鼠体内注射抗Ｌ３Ｔ４ＭｃＡｂ后，观察其对胎鼠及新生鼠脾脏细胞数量及功能的影响。结果显示：胎鼠脾脏细胞总数、ＣＤ４单阳性细胞（ＣＤ４ＳＰ）、膜表面免疫球蛋白阳性细胞（Ｓｍｌｇ＋Ｂ细胞）数量及血清Ｉｇ含量均明显减少；新生鼠脾脏细胞总数、ＣＤ４ＳＰ数量减少，但其ＳｍＩｇ＋Ｂ细胞数量无显著改变。两组小鼠脾细胞对ＣｏｎＡ、ＰＷＭ刺激的增殖反应明显减弱。胎鼠及新生鼠ＣＤ８ＳＰ数量几乎不变。提示ＣＤ４分子不单纯影响胸腺Ｔ细胞在中枢免疫器官及外周免疫器官的发育，而且对外周免疫器官中Ｂ淋巴细胞的发育及功能也有较大影响
After inoculation of anti-L3T4McAb in pregnant mice and newborn mice, the effect of their dose on the number and function of spleen cells in fetal and neonatal rats was observed. The results showed that the total number of spleen cells, the number of CD4 single positive cells (CD4SP), the number of immunoglobulin positive cells (Smlg + B cells) and the serum Ig contents of fetal rat spleens decreased significantly. The total number of spleen cells and the number of CD4SP in neonatal rats decreased but SmIg + B No significant change in cell number. The proliferative responses of splenocytes from both groups to ConA and PWM were significantly weakened. The number of fetal and neonatal mice CD8SP almost unchanged. These results suggest that CD4 molecules do not affect the development of thymus T cells in central immune organs and peripheral immune organs, but also affect the development and function of B lymphocytes in peripheral immune organs