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目的:观察应用舍雷肽酶预防下颌阻生智齿拔除术后肿胀的临床效果。方法:选择需拔除下颌阻生智齿60例,随机分为观察组和对照组各30例。对照组拔牙术后给予口服甲硝唑片0.2g,3次/d,连用3天;阿莫西林胶囊0.5g,3次/d,连用3天,进行预防性抗感染治疗。观察组在对照组治疗的基础上,给予口服舍雷肽酶肠溶片10mg,3次/d,连用7天。比较两组术后第1天、第2天及第7天面颊部肿胀程度。结果:两组术后第1天面颊部肿胀程度差异不显著(P>0.05),观察组术后第2天和第7天面颊部肿胀程度均较对照组非常显著减轻(P<0.01)。两组均未发生药物不良反应。结论:舍雷肽酶减轻下颌阻生智齿拔牙术后肿胀效果显著,且安全。
OBJECTIVE: To observe the clinical effect of using seropeptidase to prevent swelling after mandibular impacted wisdom tooth extraction. Methods: Sixty cases of mandibular impacted wisdom teeth were selected and randomly divided into observation group and control group with 30 cases each. The control group was given oral metronidazole tablets 0.2g, 3 times / d, once every 3 days; amoxicillin capsules 0.5g, 3 times / d, once every 3 days for preventive anti-infective treatment. On the basis of the treatment of the control group, the observation group was given oral administration of 10 mg salcoside enteric-coated tablets 3 times daily for 7 days. The swelling degree of the cheeks on the first day, the second day and the seventh day after the operation were compared between the two groups. Results: There was no significant difference in the degree of buccal swelling between the two groups on the first day after operation (P> 0.05). The degree of buccal swelling in the observation group on day 2 and 7 after operation was significantly lower than that of the control group (P <0.01). No adverse drug reactions occurred in both groups. Conclusion: Severe seropectomy is safe and safe with sero-peptidase in the treatment of mandibular impacted wisdom tooth extraction.