论文部分内容阅读
华法林是常用口服抗凝剂,在临床广泛应用,作用机制主要影响外源性凝血系统,与维生素K相互竞争,抑制部分凝血因子的合成过程,使凝血因子合成减少,发挥抗凝作用。但过量或使用不当又会导致出血。而出血发生率取决于抗凝程度、用药持续时间、病人的情况、实验室检测的准确度以及药物之间的反应等。其处理方法:建议用适量的维生素K,和输新鲜血浆治疗。因病需要长期口服华法林时,必须在医务人员正确指导下,定期监测,不断调整。全方位认识华法林,正确使用华法林意义重大。
Warfarin is a commonly used oral anticoagulant, widely used in clinical practice, the mechanism of action mainly affects the extrinsic coagulation system, competing with vitamin K, inhibiting the synthesis of some coagulation factors, reducing the synthesis of coagulation factors and exerting anticoagulant effect. However, excessive or improper use can cause bleeding. The bleeding rate depends on the degree of anticoagulation, medication duration, the patient’s condition, the accuracy of laboratory tests and drug reactions. The treatment: It is recommended to use the right amount of vitamin K, and lose fresh plasma treatment. Long-term oral administration of warfarin due to illness, the medical staff must be under the correct guidance, regular monitoring, continuous adjustment. The full understanding of warfarin is of great significance in the proper use of warfarin.