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目的:探讨血清基质金属蛋白酶-9(MMP-9)在急性脑梗死发病不同时间的动态变化及临床意义。方法:急性脑梗死患者32例设立为观察组,对照组选择健康体检者32例作为研究对象,分别检测两组入院时、第2-3天、第4-7天血清MMP-9的浓度变化水平。结果:观察组患者入院时血清MMP-9明显高于对照组,差异有显著性(P<0.01)。发病后第2-3天MMP-9水平逐渐升高,发病后的第4-7天出现降低。对各时间点的血清MMP-9水平进行方差分析,结果显示,发病第2-3天的血清MMP-9水平高于入院时及发病第4-7天时间点,但与对照组比较,差异无显著性(P>0.05)。MMP-9与神经功能缺损程度评分的相关系数为r=-0.734,神经功能缺损评分与MMP-9浓度C呈负相关,差异有显著性(P<0.01)。结论:MMP-9在急性脑梗死的病理生理过程中起重要作用,可作为判断脑梗死神经功能损伤程度的指标之一,临床上早期测定脑梗死外周血中MMP-9水平,有助于判断预后。
Objective: To investigate the dynamic changes of serum matrix metalloproteinase-9 (MMP-9) in acute cerebral infarction at different times and its clinical significance. Methods: Thirty-two patients with acute cerebral infarction were enrolled in the observation group and 32 healthy volunteers were selected as the control group. Serum levels of MMP-9 were measured at the first 2-3 days and the fourth 4-7 days after admission Level. Results: The serum MMP-9 level in the observation group was significantly higher than that in the control group at admission (P <0.01). After the onset of 2-3 days MMP-9 levels gradually increased, the incidence of 4-7 days after the decrease. The analysis of variance of serum MMP-9 level at each time point showed that the level of serum MMP-9 in the 2-3th day after onset was higher than that at admission and 4-7 days after onset, but compared with the control group, the difference No significant (P> 0.05). The correlation coefficient between MMP-9 and neurological deficit score was r = -0.734. Neurological impairment score was negatively correlated with MMP-9 concentration C (P <0.01). Conclusion: MMP-9 plays an important role in the pathophysiological process of acute cerebral infarction and can be used as an index to judge the degree of neurological damage in cerebral infarction. It is helpful to determine the level of MMP-9 in the peripheral blood of patients with cerebral infarction Prognosis.