表达猴肾病毒40巨大T-抗原(Tag)的转基因鼠,在胰岛素基因调节区控制下,为肿瘤发生提供了一个很有用的模型。所有胰岛都表达Tag,尽管起初并无异常增生。但是,一半以上的胰岛逐渐开始增生,一小部分(大约10％)神经血管分化最终导致十四周以后1～2％的胰岛形成了血管丰富的硬癌。最初促发增生与局部类胰岛素生长因子Ⅱ(IGF-Ⅱ)的激活有关。用反义寡核苷 Transgenic mice that express the 40 T-antigens of monkey kidney virus, under the control of insulin gene regulatory regions, provide a useful model for tumorigenesis. All islets express Tag, although there was no abnormal proliferation at first. However, more than half of the islets began to proliferate, and a small fraction (approximately 10%) of neurovascular differentiation eventually led to the formation of blood-vessel-rich hard cancers in 1 to 2% of islets after 14 weeks. Initial pro-hyperplasia was associated with activation of local insulin-like growth factor II (IGF-II). Antisense oligonucleosides