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目的探讨血液灌流联合血液透析治疗急性中毒引起肾功能衰竭的临床效果。方法 52例急性肾功能衰竭患者,随机分为对照组和观察组,各26例。对照组给予常规血液透析治疗,观察组给予血液灌流联合血液透析治疗。对两组患者的治疗效果进行比较。结果治疗后观察组总有效率96.2%高于对照组73.1%(P<0.05)。治疗后观察组和对照组C反应蛋白(CRP)[(23±4)、(88±13)mg/L],中分子物质(MMS)[(263±31)、(331±40)U/dl],肌酐(Cr)[(222±12)、(438±82)μmol/L],肌红蛋白(Mb)[(68±9)、(104±9)mg/L],钾离子(K~+)[(4.0±0.3)、(5.2±0.5)mmol/L]均较治疗前降低(P<0.05);且观察组下降幅度较对照组更明显(P<0.05)。结论急性中毒引起的肾功能衰竭患者采用血液灌流联合血液透析的方法治疗可有效改善患者的相关生化指标,治疗疗效确切,可在临床中推广应用。
Objective To investigate the clinical effects of hemoperfusion combined with hemodialysis in the treatment of acute renal failure caused by poisoning. Methods 52 patients with acute renal failure were randomly divided into control group and observation group, with 26 cases in each. The control group was given routine hemodialysis, and the observation group was given hemoperfusion combined with hemodialysis. The treatment effect of two groups of patients were compared. Results After treatment, the total effective rate in observation group was 96.2% higher than that in control group (73.1%, P <0.05). After treatment, the levels of C reactive protein (CRP) [(23 ± 4), (88 ± 13) mg / L] and MMS in serum of 263 ± 31 and 331 ± 40 U / dl], creatinine ([222 ± 12], (438 ± 82) μmol / L], myoglobin [(68 ± 9), (104 ± 9) mg / L] (4.0 ± 0.3) and (5.2 ± 0.5) mmol / L, respectively, compared with that before treatment (P <0.05), and the decrease in the observation group was more significant than that in the control group (P <0.05). Conclusion Acute poisoning caused by renal failure in patients with hemoperfusion combined with hemodialysis treatment can effectively improve the patient’s biochemical indicators, the treatment effect is exact, it can be extended to clinical application.