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采用双侧颈总动脉和椎动脉夹闭加全身降压建立的脑缺血模型研究钙通道拮抗剂尼莫地平对犬完全性脑缺血后脑血流量（CBF）、脑匀浆三磷酸腺苷（ATP）和神经机能恢复的影响。全麻药为硫喷妥钠20mg／kg和琥珀酰胆碱0．1g静注，气管插管机械控制呼吸。脑缺血15分钟后（恢复灌流后），缺血对照组（B组和C组，犬各6只）动物生理盐水静脉滴入，尼莫地平治疗组以尼莫地平20μg／kg，半量立即静注，另半量30分钟内静脉滴入（D组和E组，犬各6只）。其中C组和E组动物颅骨开窗备取脑皮层组织。复灌后120分钟治疗组动物的CBF和脑ATP比对照组动物显著增高，神经缺陷积分和存活数比对照组略好，但差异无显著性。结果表明，尼莫地平有助于犬脑缺血15分钟后CBF的改善和脑ATP的恢复，但尚不足以明显改善神经机能和提高存活率。
To investigate the effect of nimodipine, a calcium channel antagonist, on cerebral blood flow (CBF), brain homogenate ATP (ATP) in dogs with bilateral common carotid artery and vertebral artery occlusion plus systemic blood pressure lowering. And neurological recovery. General anesthetics for thiopental 20mg / kg and succinylcholine 0.1g intravenous injection, mechanical control of endotracheal intubation. Fifteen minutes after cerebral ischemia (after reperfusion), animals in the ischemic control group (B group and C group, six dogs in each group) received intravenous instillation of normal saline. In the nimodipine treatment group, nimodipine 20 μg / kg, Intravenous injection, the other half within 30 minutes of intravenous infusion (D group and E group, 6 dogs each). Among them, the skulls of C and E animals were taken out for cortical tissue. After 120 minutes of reperfusion, the CBF and brain ATP in the treatment group were significantly higher than those in the control group, and the neurological deficit score and survival number were slightly better than those in the control group, but the difference was not significant. The results show that nimodipine can help to improve the CBF after 15 minutes of cerebral ischemia and brain ATP recovery, but not enough to significantly improve nerve function and improve survival.