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目的探讨孕早期母体甲状腺激素水平与孕中期增重的相关性。方法选择行孕期保健的孕妇2 533例,检测其孕早期、孕中期和孕晚期甲状腺激素水平,包括游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)和促甲状腺激素(TSH)。采用Pearson相关及混合线性效应回归模型分析孕早期母体甲状腺激素水平与孕中期增重的关系。结果随着孕期的增长,孕妇血清TSH逐渐升高,FT_3和FT_4逐渐降低,差异均有统计学意义(均P<0.05)。经Pearson相关分析,无论整体还是BMI分层下,孕早期TSH、FT_3、FT_4与孕中期增重均无相关性(均P>0.05),调整孕妇年龄、BMI、分娩孕周、孕周差及TSH、FT_3、FT_4影响后,经线性回归分析,孕早期TSH、FT_3、FT_4水平与孕中期增重亦均无相关性(均P>0.05)。结论孕早期母体甲状腺激素水平与孕中期增重没有相关性。
Objective To investigate the correlation between the level of maternal thyroid hormone in the first trimester and the weight gain in the second trimester. Methods Totally 2 533 pregnant women were enrolled in this study. Thyroid hormones including free triiodothyronine (FT_3), free thyroxine (FT_4) and thyrotropin (TSH) were detected in early pregnancy, second trimester of pregnancy and third trimester of pregnancy. . Pearson correlation and mixed linear regression model were used to analyze the relationship between the level of thyroid hormone in the first trimester and the weight gain in the second trimester. Results With the increase of pregnancy, serum TSH of pregnant women gradually increased, FT_3 and FT_4 gradually decreased, the differences were statistically significant (all P <0.05). Pearson correlation analysis showed that there was no correlation between TSH, FT_3 and FT_4 in the first trimester and the second trimester of pregnancy (both P> 0.05) either in the whole body or in the BMI stratification. Adjusting the age, BMI, gestational weeks, After TSH, FT_3 and FT_4 influence, there was no correlation between TSH, FT_3 and FT_4 levels in the first trimester and the second trimester weight gain (all P> 0.05) after linear regression analysis. Conclusion There is no correlation between maternal thyroid hormone level in early pregnancy and weight gain in the second trimester.