论文部分内容阅读
世界范围内宫颈癌是仅次于乳腺癌的妇科恶性肿瘤,在我国每年新增宫颈癌约13.5万例,占全球发病数量的1/3,约8万人死亡~([1-3])。1974年德国病毒学家Zur Hausen等~([4])提出了人乳头状瘤病毒(human papilloma virus,HPV)可能与宫颈癌发病有关的设想。随着宫颈癌的研究不断深入,证实,99.8%宫颈癌活检标本中可以检测到HPV-DNA~([5])。目前,通过无创性获取宫颈黏液进行高危型HPV-DNA检测是筛查高危型HPV感染的可靠检测方法。那么年龄因素对高危型HPV-DNA阳性率的
Cervical cancer in the world is second only to breast cancer gynecological malignancies, an annual increase of about 135,000 cases of cervical cancer in our country, accounting for the incidence of the world’s 1/3, about 80,000 death ~ ([1-3]) . 1974 German virologist Zur Hausen et al. [4] proposed that human papilloma virus (HPV) may be associated with the development of cervical cancer. With the research of cervical cancer deepening, it is confirmed that 99.8% of cervical cancer biopsy specimens can detect HPV-DNA ~ ([5]). Currently, noninvasive access to cervical mucus for high-risk HPV-DNA testing is a reliable screening test for high-risk HPV infection. Then the age factor for high-risk HPV-DNA positive rate