已知脂质的过氧化作用具有破坏性后果。例如将肝微粒体与NADPH一起温培,若无接受电子的底物存在,将使微粒体脂质发生过氧化作用。若向其中加入红细胞,则发生溶血。在整体内,当肝细胞微粒体脂质发生过氧化时,可引起线粒体破坏,细胞内可溶性酶溢入血浆,溶酶体解体,核破裂等。在许多病理情况下的器宫损害可能与此有关。但微粒体中脂质的过氧化如何导致远位病理损害,机制尚不清楚。一种意见认为,这是由于在微粒体 Lipid peroxidation is known to have destructive consequences. For example, liver microsomes are incubated with NADPH, and if no electron-accepting substrate is present, the microsomal lipid undergoes peroxidation. If red blood cells are added thereto, hemolysis occurs. In the whole body, when the liver cell lipid peroxidation occurs, it can cause damage of mitochondria, intracellular soluble enzyme overflow into plasma, lysosome disintegration and nuclear rupture. Palace lesions in many pathological conditions may be related to this. But how lipid peroxidation in microsomes leads to distant pathological damage is unclear. One opinion is that this is due to microsomes