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目的:探讨循环肿瘤细胞CTCs在晚期转移性乳腺癌中的应用价值。方法:Cell Search系统检测本院40例复发转移性乳腺癌患者的CTCs水平,比较复发转移性乳腺癌患者血液中CTCs的差异,分析复发转移性乳腺癌患者CTCs与其疾病特征及预后的关系。结果:Cell Search系统检测复发转移性乳腺癌患者外周血CTCs阳性率达42.5%;在复发转移性乳腺癌患者中,CTCs≥5个/7.5 mL者的肝脏转移、骨转移、转移灶≥3处均较CTCs<5个/7.5 mL者更高(P<0.05),前者的PFS较之后者也表现出强烈的缩短趋势(X2=3.573,P=0.059),而肺转移、淋巴结转移、脑转移、胸壁复发、受体及HER2表达在两组间无差异。结论:Cell Search系统展现出较好的检测复发转移性乳腺癌患者外周血CTCs的能力。在复发转移性乳腺癌患者中,CTCs的高检出率与腹腔脏器转移、肝转移、骨转移相关。CTCs≥5个/7.5 mL患者的预后很可能要差于CTCs<5个/7.5 mL者。
Objective: To investigate the value of circulating tumor cells CTCs in the treatment of advanced metastatic breast cancer. Methods: The CTCs of 40 patients with recurrent metastatic breast cancer in our hospital were detected by Cell Search system. The differences of CTCs in patients with recurrent metastatic breast cancer were compared. The relationship between CTCs and the disease characteristics and prognosis was analyzed. Results: The positive rate of CTCs in peripheral blood of patients with recurrent metastatic breast cancer was 42.5% in the Cell Search System. In the patients with recurrent metastatic breast cancer, the liver metastases, bone metastases and metastases ≥3 in CTCs≥5 /7.5 mL (P <0.05). Compared with the latter, PFS of the former also showed a strong tendency of shortening (X2 = 3.573, P = 0.059), while lung metastasis, lymph node metastasis, brain metastasis , Chest wall recurrence, receptor and HER2 expression no difference between the two groups. CONCLUSIONS: The Cell Search System demonstrated a better ability to detect CTCs in peripheral blood in patients with recurrent metastatic breast cancer. In patients with recurrent metastatic breast cancer, the high detection rate of CTCs is associated with abdominal organ metastases, liver metastases, and bone metastases. Patients with CTCs ≥5 /7.5 mL are likely to have worse prognosis than those with CTCs <5 /7.5 mL.