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磺胺二甲基啶嘧(SM_2)是一种有效的抑菌剂,但几乎无抗真菌作用。故制成的混悬液在贮存过程中,常常由于 SM_2微粒对于防腐剂的吸附而导致制剂败坏变质。本文作者设计了婴儿用 SM_2混悬液的新处方:SM_2(细粉)10g.复方西黄蓍胶散4 g、聚乙烯吡咯烷酮(PVP)2.5g 十二烷基硫酸钠0.02g,单糖浆20ml、苋菜红溶液1ml,枸橼酸0.15g,苯甲酸溶液2ml,氯仿醑5ml.香草醛香精1ml.加水至100ml。作者对该制剂进行了稳定性和抗微生物效能的一系列研究。用量筒法在24℃进行沉降容积测定,观察到混悬液在8周内很少沉降,保持了很好的可倾性与流动性;用 Brookfield HVT 粘度计通过流变学的
Sulfadimethoxine (SM 2) is a potent bacteriostat but has almost no antifungal effects. Therefore, the suspension prepared during storage, often due to SM_2 particles for the adsorption of preservatives leading to spoilage deterioration. The authors designed a new prescription for SM_2 suspensions for infants: SM 2 (powder) 10 g, compound tragacanth powder 4 g, polyvinylpyrrolidone (PVP) 2.5 g, sodium lauryl sulfate 0.02 g and single syrup 20 ml , Amaranth red solution 1ml, citric acid 0.15g, benzoic acid solution 2ml, chloroform 醑 5ml. Vanillin flavor 1ml. Add water to 100ml. The authors conducted a series of studies on the stability and antimicrobial efficacy of this formulation. Sedimentation volume was measured at 24 ° C using a graduated cylinder method and the suspension was observed to seldom settle within 8 weeks with good holdability and fluidity maintained; rheology was measured using a Brookfield HVT viscometer