目的探讨小儿感染性心内膜炎的临床治疗方法及其疗效。方法根据不同的致病菌给予相应的抗生素治疗,抗菌治疗后病情未能得到控制甚至出现恶化的给予手术治疗。结果 46例患儿,治愈28例,占60.9%;好转14例,占30.4%;自动转院2例,占4.3%;死亡2例,占4.3%,总有效率为91.3%。结论早期诊断,并给予足量的抗生素治疗或者手术治疗可有效控制感染、提高治愈率。 Objective To investigate the clinical treatment of infantile infective endocarditis and its efficacy. Methods According to different pathogens to give the appropriate antibiotics, antimicrobial therapy failed to control or even worsened to give surgical treatment. Results 46 cases of children, 28 cases were cured, accounting for 60.9%; 14 cases improved, accounting for 30.4%; 2 cases automatically transferred to hospital, accounting for 4.3%; 2 died, accounting for 4.3%, the total effective rate was 91.3%. Conclusion Early diagnosis, and give adequate antibiotic treatment or surgical treatment can effectively control the infection and improve the cure rate.