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目的探讨炎症因子水平在妊娠期高血压疾病发病中的意义。方法采用ELISA法测定90例妊娠期高血压疾病患者(妊娠期高血压、子痫前期、子痫患者各30例)及30例健康孕妇(对照组)血清白细胞介素(IL)-1β、IL-10、肿瘤坏死因子α(TNF-α)及髓过氧化物酶(MPO)水平并加以比较。结果 (1)与对照组比较,妊娠期高血压组、子痫前期组及子痫组患者血清IL-1β、TNF-α及MPO水平均升高(P均<0.05),且在3组间有逐渐增高趋势,以子痫组患者IL-1β、TNF-α及MPO水平最高。(2)与对照组比较,妊娠高血压组、子痫前期组及子痫组患者血清IL-10水平均降低,其中子痫前期组及子痫组IL-10水平差异有统计学意义(P均<0.01),而妊娠高血压组差异无统计学意义(P>0.05)。结论妊娠期高血压疾病患者血清炎症因子水平的改变可能与妊娠期高血压疾病严重程度有关,IL-1β、IL-10、TNF-α及MPO可以作为评估妊娠期高血压疾病严重程度的预测指标。
Objective To investigate the significance of inflammatory cytokines in the pathogenesis of hypertensive disorder complicating pregnancy. Methods Serum levels of interleukin (IL) -1β, IL-1β in 90 patients with gestational hypertension (gestational hypertension, preeclampsia and eclampsia) and 30 healthy pregnant women (control group) were measured by ELISA. -10, tumor necrosis factor alpha (TNF-α) and myeloperoxidase (MPO) levels were compared and compared. Results (1) Compared with the control group, the serum levels of IL-1β, TNF-α and MPO in hypertensive pregnancy group, preeclampsia group and eclampsia group were significantly increased (all P <0.05) With the trend of increasing gradually, the levels of IL-1β, TNF-α and MPO in eclampsia group were the highest. (2) Compared with the control group, the levels of IL-10 in the pregnancy-induced hypertension group, the preeclampsia group and the eclampsia group were decreased, and the levels of IL-10 in the preeclampsia group and the eclampsia group were significantly different (P All <0.01), while there was no significant difference in gestational hypertension group (P> 0.05). Conclusions The changes of serum inflammatory cytokines in patients with hypertensive disorders of pregnancy may be related to the severity of hypertensive disorders in pregnancy. IL-1β, IL-10, TNF-α and MPO may be used as predictors of the severity of hypertensive disorders in pregnancy .