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心得平(OXPrenolol,“Trisicor”)系一新的β-受体阻滞药。本文采用自身对照法观察20例轻度及中度高血压患者(舒张压95～140毫米汞柱,收缩压160～220毫米汞柱),单用心得平的效果。试验前后分为3个阶段,第1阶段给予安慰剂2周;第2阶段给用心得平, 每日80～320毫克,分4次口服,共14～28周;第3阶段仍改用安慰剂4周。观察期间每隔2周检查血压和心率,每隔4周检查血象、血浆总蛋白、血尿素氮、肌酐、电解质、谷丙转氨酶、谷草转氨酶、空腹血糖、尿及心电图等。结果表明,根据患者对药物的治疗反应,可分为“有反应者”(13例)和“无反应者”(7例)。“有反应者”多属轻度或不稳定型高血
OXPrenolol (“Trisicor”) is a new beta-blocker. In this paper, 20 cases of mild and moderate hypertension (diastolic blood pressure 95 ~ 140 mmHg, systolic blood pressure 160 ~ 220 mmHg) were observed by self-control method, and the effect was flat only. The first phase before and after the test was divided into three phases, the first phase of placebo for 2 weeks; the second phase of the experience flat, 80 to 320 mg daily, orally 4 times a total of 14 to 28 weeks; the third phase is still used to console 4 weeks. Blood pressure and heart rate were examined every 2 weeks during the observation period. Blood samples, plasma total protein, blood urea nitrogen, creatinine, electrolyte, alanine aminotransferase, aspartate aminotransferase, fasting blood glucose, urine and electrocardiogram were inspected every 4 weeks. The results showed that there were 13 responders and 7 nonresponders, based on the patient’s response to the drug. “Responders” are mostly mild or unstable high blood