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目的通过对2010-2013年间宁波市江东区产前筛查情况的分析,了解孕妇中筛查出的神经管畸形(NTD)、18三体综合征、21三体综合征的情况,及随访出生后的实际情况,以探索有效的预防措施。方法静脉采集年龄〈35岁,孕中期15-20周孕妇血液3ml,检测AFP,β-HCG和uE3三项指标,结合预产期、体重、年龄,B超等估算出孕妇怀有三种缺陷胎儿的风险率。结果 4年间,参与血清筛查的孕妇9945人,筛查率91.9%,NTD高风险39人,18三体高风险19人,21三体高风险462人,高风险随访确诊,NTD 4人,18三体3人,21三体8人。低风险随访确诊,NTD1人,18三体0人,21三体1人。结论产前筛查和诊断能早期发现三种缺陷的风险,及时干预,减少出生缺陷。
Objective To analyze the situation of prenatal screening in Jiangdong District of Ningbo City during 2010-2013 to find out the neural tube defects (NTD), trisomy 18 and trisomy 21 in pregnant women, After the actual situation, to explore effective preventive measures. Methods The blood samples of pregnant women <35 years old and 15-20 weeks of pregnancy were collected intravenously. The three indexes of AFP, β-HCG and uE3 were detected. The pregnant women were estimated to have the risk of three kinds of defective fetuses according to the expected date of birth, weight, age and B- rate. Results In 4 years, there were 9,945 pregnant women who were screened for serological screening, with a screening rate of 91.9%. There were 39 high risk NTDs, 19 high risk trisomy 18, 462 high risk trisomy 21, high risk follow-up, 4 NTDs, Body 3 people, 21 trisomy 8 people. Low-risk follow-up diagnosis, NTD1 people, 18 trisomy 0, 21 trisomy 1. Conclusions Prenatal screening and diagnosis can early detect the risk of three defects, timely intervention and reduce birth defects.