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过敏性紫癜(Henoch-Sch?nlein purpura，HSP)是一种IgA相关的小血管性白细胞碎裂性血管炎，常见于儿童，发病机制与B细胞介导的体液免疫应答紊乱密切相关。作为具有辅助B细胞功能的CD4n +T细胞，其各个亚群都具有独特的促进或调节机体免疫炎症反应的功能。在HSP患者体内CD4n +T细胞各亚群的比例存在异常变化，其中Th1/Th2比例失衡，Th17和Tfh细胞比例升高，Treg细胞比例下降等改变与HSP疾病的发生、发展和临床表型密切相关。因此CD4n +T细胞亚群的检测对于指导HSP病情的评估具有重要的意义，有望为HSP的临床诊断和个体化治疗提供新思路。n “,”Henoch-Sch?nlein purpura(HSP)is an IgA-associated leukocytoclastic small-vessel vasculitis, commonly occurred in children.Recent studies have shown that its pathogenesis is closely related to the disturbance of humoral immune response mediated by B cells.CD4n + T cells have the function of help B cells.Each subgroup of CD4n + T cells has unique functions of promoting or regulating immune inflammatory response.There are abnormal changes in the proportion of CD4n + T cells subsets in HSP patients, including the imbalance of Th1/Th2, increasing numbers of Th17 and Tfh cells, together with decreasing Treg cell numbers.The changes are closely related to the occurrence, development and the clinical phenotype of HSP.It is suggested that the detection of CD4n + T cells plays critical roles in guiding the evaluation of HSP, and is expected to provide a new idea for the clinical diagnosis and individualized treatment of HSP.n