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目的通过检测转化生长因子β1(TGF-β1)和结缔组织生长因子(CTGF)在原发性干燥综合征肺间质病变(PSS-ILD)患者血清中的表达水平,并探讨其意义。方法采用ELISA法检测120例原发性干燥综合征(PSS)(包括54例PSS-ILD)和36例健康体检者血清TGF-β1,CTGF的表达水平。结果 PSS-ILD组中TGF-β1,CTGF的含量分别为(14.31±4.05)mg/L,(70.17±30.64)mg/L,均高于对照组,差异有统计学意义(P<0.01);TGF-β1和CTGF对PSS-ILD诊断的灵敏度为76.0%,54.9%,特异度为63.4%,82.4%.结论 TGF-β1和CTGF参与PSS-ILD的发生发展过程,可作为早期筛查PSS-ILD的指标之一。
Objective To detect the expression of transforming growth factor β1 (TGF-β1) and connective tissue growth factor (CTGF) in the serum of patients with primary interstitial lung disease (PSS-ILD) and to explore its significance. Methods Serum levels of TGF-β1 and CTGF were detected by ELISA in 120 patients with PSS (including 54 PSS-ILD) and 36 healthy controls. Results The levels of TGF - β1 and CTGF in PSS - ILD group were (14.31 ± 4.05) mg / L and (70.17 ± 30.64) mg / L, respectively, which were significantly higher than those in control group (P <0.01). The sensitivity of TGF-β1 and CTGF for the diagnosis of PSS-ILD was 76.0%, 54.9%, specificity of 63.4%, 82.4% .Conclusion TGF-β1 and CTGF are involved in the development of PSS-ILD, One of the indicators of ILD.