附子是毛茛科植物乌头的子根,中医常用于治疗“阳衰欲脱、脉微欲绝”等症。大量的药理试验及临床实践都证明附子具有明显的强心作用。1976年 Takuo Kosuge 等从附子中分离出去甲乌药碱(higenamine,附子一号)。他们认为这是附子的强心有效成分。为了进一步探讨其药理作用,寻找更有效的治疗心血管疾病的药物,我们合成了附子一号并进行了药理试 Aconite is the sub-root of Aconitum, a species of Ranunculaceae. It is commonly used in Chinese medicine to treat the symptoms of “decrease in sensibility, pulse, and desire to be absent”. A large number of pharmacological tests and clinical practice have shown that the aconite has a significant cardiac effect. In 1976 Takuo Kosuge et al. isolated aconitine (Higenamine, Fuzi No. 1) from aconite. They think this is a strong and effective component of Aconite. In order to further explore its pharmacological effects and find more effective drugs for the treatment of cardiovascular diseases, we synthesized Fuzi No. 1 and conducted a pharmacological test.