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目的 探讨心气虚证动物模型的建立方法。方法 SD大鼠 4 0只采用基础进食量 2 4d ,每日按自身体重的5 %强迫负重游泳至力竭 ,大剂量灌服心得安 2 4mg 10 0g等综合方法建立心气虚证动物模型 ,其中 2 0只作为人参药物反证组。并设立正常对照组 4 0只 ,以进一步证明所建立模型是心气虚证动物模型。结果 与正常对照组比较 ,模型组大鼠心脏收缩功能和舒张功能均有所下降 ,反映虚证的SOD含量减少 ,MDA含量增加。而所有定量指标均发生了符合心气虚证的变化。结论 采用基础进食量、强迫负重游泳及大剂量灌服心得安的综合方法建立心气虚证动物模型是可行的
Objective To investigate the establishment of animal models of heart qi deficiency syndrome. Methods 40 SD rats were fed with the basal diet for 24 days. Each day, rats were forced to swim by 5% body weight to exhaustion. The animal model of heart Qi deficiency syndrome 20 only as a ginseng anti-card group. And set up a normal control group of 40, to further prove that the model is established animal model of heart qi deficiency. Results Compared with the normal control group, the systolic and diastolic function of the model rats decreased, which reflected that SOD decreased and MDA content increased. And all the quantitative indicators have occurred in line with changes in heart Qi deficiency. Conclusion It is feasible to establish the animal model of heart qi deficiency syndrome by the comprehensive method of basic food intake, forced weight swimming and high dosage of prophylaxis