基质金属蛋白酶(MMPs)是一组含锌的能降解细胞外基质(ECM)的中性蛋白酶的基因家族,现已发现20多种,根据蛋白质结构可分为五个大类,即基质溶解酶、胶原酶、明胶酶、膜型酶和其他不能分类的基质酶,MMPs能降解几乎所有的细胞外基质,具有很重要的生理功能和病理作用。生理条件下,参与胚胎发生、正常组织重塑、创伤愈合和血管发生,在病理条件下,参与纤维变性、关节炎等的病理 Matrix metalloproteinases (MMPs) are a family of zinc-containing neutral proteases that can degrade extracellular matrix (ECM), and more than 20 have been found. According to the protein structure, MMPs can be divided into five major groups, namely, matrix lytic enzyme , Collagenase, gelatinase, membranous enzymes and other unclassified substrate enzymes, MMPs can degrade almost all extracellular matrix, and have important physiological functions and pathological functions. Physiological conditions, involved in embryogenesis, normal tissue remodeling, wound healing and angiogenesis, in pathological conditions, involved in fibrosis, arthritis and other pathology