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目的探讨何首乌所致肝损害的例临床特征。方法分析2006-2010年收治的何首乌所致的肝损害12例临床资料。结果何首乌所致的药物性肝损害潜伏期为15~90 d,主要临床表现为乏力、纳差、皮肤巩膜黄染,4例伴有皮肤瘙痒,肝大3例,腹水l例;肝功能酶学明显升高,以ALT升高为主,大多数有黄疸,以直接胆红素升高为主,重症药物性肝损害2例。结论何首乌可引起肝功能损害,多数伴有黄疸,本病预后较好。
Objective To investigate the clinical characteristics of liver damage caused by Polygonum multiflorum. Methods The clinical data of 12 cases of liver damage caused by Polygonum multiflorum admitted from 2006 to 2010 were analyzed. Results Polygonum multiflorum caused by drug-induced liver damage latency of 15 ~ 90 d, the main clinical manifestations of fatigue, anorexia, scleral skin yellow, 4 cases associated with pruritus, liver enlargement in 3 cases, 1 case of ascites; liver function enzyme Significantly elevated to ALT-based, most have jaundice, mainly to direct bilirubin, severe drug-induced liver damage in 2 cases. Conclusion Polygonum multiflorum can cause liver damage, most associated with jaundice, the prognosis of this disease is better.