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目的 补肾中药用于实验性继发性骨质疏松症模型大鼠 ,观察其疗效 ,并对补肾中药的机理做初步的探讨。方法 使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型 ,同时分别给予维生素 D3、补肾中药“骨密片”治疗 3月后 ,观察模型动物全身、腰椎及股骨骨密度 ( BMD)、三点弯曲试验、血钙、血磷、血 AKP等理化指标。结果 中药及中西医结合治疗组大鼠血钙、血磷、血 AKP等均高于模型组 ( P<0 .0 5) ,腰椎及股骨 BMD以及三点弯曲试验也高于模型组 ( P<0 .0 5) ,但整体 BMD和模型组没有明显差异 ( P>0 .0 5)。结论 补肾中药能在承重骨 BMD等方面在一定程度上缓解由肾上腺皮质激素诱发的骨质疏松症
Objective To observe the effect of kidney-reinforcing traditional Chinese medicine for experimental secondary osteoporosis model rats and to discuss the mechanism of kidney-reinforcing traditional Chinese medicine. Methods Animal models of secondary osteoporosis were made by intramuscular injection of glucocorticoids. After three months of treatment with vitamin D3 and kidney-bubble medicine “Bone-Tail Tablets,” respectively, the body mass, lumbar spine and femoral bone mineral density (BMD) were observed. Three-point bending test, blood calcium, blood phosphorus, blood AKP and other physical and chemical indicators. RESULTS: Blood calcium, phosphorus, blood AKP were higher in the traditional Chinese medicine and integrated traditional Chinese and Western medicine treatment groups than in the model group (P<0.05), and the lumbar and femoral BMD and three-point bending test were also higher than those in the model group (P< 0 .0 5) , but there was no significant difference between the overall BMD and the model group (P > 0.05). Conclusion Chinese herbal medicine for tonifying kidney can relieve osteoporosis induced by adrenocorticotropic hormone to a certain extent in bearing BMD and other aspects.