论文部分内容阅读
手术治疗局限性肾细胞癌时需优先考虑保留肾脏功能。既往研究表明血管内皮生长因子(VEGF)靶向药物能缩小转移性肾细胞癌的瘤体。那么VEGF或许对局限性肾细胞癌亦有此疗效,从而达到在肾部分切除术时对肾功能进行最大限度保护。为验证这一假设,研究者对局限性肾透明细胞癌患者进行了一项前瞻性Ⅱ期临床试验。纳入研究的患者需满足下列条件之一或全部:肾根治性或部分切除术后可能
Surgical treatment of localized renal cell carcinoma need to give priority to retain renal function. Previous studies have shown that vascular endothelial growth factor (VEGF) targeted drugs can shrink the tumor of metastatic renal cell carcinoma. Then VEGF may have this effect on localized renal cell carcinoma, so as to achieve maximum protection of renal function in partial nephrectomy. To test this hypothesis, the investigators conducted a prospective phase II clinical trial of patients with localized renal clear cell carcinoma. Patients enrolled in the study should meet one or both of the following criteria: Kidney radical or partial resection