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采用紫外光谱法选择丙烯酰胺为功能单体,以二苯甲酰-D-酒石酸(D-DBTA)为模板分子,丙烯酰胺为功能单体,二甲基丙烯酸乙二醇酯为交联剂,甲苯和十二醇为混合致孔剂,用原位分子印迹技术,合成了D-DBTA分子印迹整体聚合物。在优化色谱条件的基础上,25min内基本实现了DBTA消旋体的手性分离,分离度达1.25。对色谱分离过程中的热力学进行分析,在所考察的温度范围内,色谱分离存在两种不同的热力学过程,且两者与范特霍夫方程能够很好地吻合。在这两种热力学过程的转换温度处,分离因子α达最大值。
UV-spectrum was used to select acrylamide as functional monomer, dibenzoyl-D-tartaric acid (D-DBTA) as template, acrylamide as functional monomer and ethylene glycol dimethacrylate as crosslinking agent, Toluene and dodecyl alcohol as a mixed porogen, using in-situ molecular imprinting technology, the synthesis of D-DBTA molecularly imprinted monolithic polymer. Based on the optimization of chromatographic conditions, chiral separation of DBTA racemate was achieved within 25 min with a resolution of 1.25. In the analysis of thermodynamics during the chromatographic separation process, there are two different thermodynamic processes in the chromatographic separation in the investigated temperature range, and the two are in good agreement with the van der Hoeff equation. At the transition temperatures of these two thermodynamic processes, the separation factor α reaches a maximum.