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目的：为观察脊髓拴系综合征患儿终丝及脂肪团块的病理改变，探讨其发病机制。方法：对１８例患儿术中取材，行光镜、电镜观察。结果：发现在终丝末端及脂肪瘤内，光镜下可见有大量的各种形态神经组织分布；电镜下见终丝内神经纤维髓鞘厚薄不均、电子密度高低不等，轴浆内线粒体呈缺氧性改变；随年龄增长，病理改变加重。结论：观察证实了神经被拴系、神经缺血、缺氧改变为本病的病理基础及本病早期治疗的必要性
OBJECTIVE: To investigate the pathological changes of terminal filaments and fat masses in children with TMS syndrome and to explore its pathogenesis. Methods: 18 cases of children were taken during surgery, light microscope, electron microscope observation. RESULTS: It was found that a large number of various morphological nerve tissue distributions were observed under light microscopy at the end of terminal silk and in lipomas; under the electron microscope, the thickness of the myelin sheath of nerve fibers in the terminal silk was uneven, and the electron density was varied. The mitochondria in the axon were observed. Hypoxia changes; with age, pathological changes worsened. Conclusions: The observations confirmed that the nevus system, nerve ischemia, and hypoxia changed the pathological basis of this disease and the necessity of early treatment of this disease.