氯氮平常致流涎副反应 ,发生率达 6 4 3% [1] ,这严重影响了病人治疗的依从性 ,并可导致吸入性肺炎。有报道谷维素对氯氮平所致的流涎副反应有较好的疗效[2 ] 。为进一步验证谷维素的疗效 ,我们对其和多虑平治疗氯氮平所致的流涎副反应进行了双盲对照研究 ,现报道如下。1　资料 Clozapine often causes side effects of salivation, with an incidence of 64.3% [1], which seriously affects the patient’s compliance with treatment and can lead to aspiration pneumonia. It is reported that oryzanol on clozapine side effects caused by salivation have a good effect [2]. In order to further verify the efficacy of oryzanol, we conducted a double-blind controlled study of its side effects due to clozapine treatment with doxepin and are reported below. 1 data