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采用不脱钙骨切片技术，配合四环素双标记和骨组织形态计量学及铝染色，研究了不同的铝浓度在肾功能正常与肾功能不全时对诱导性异位骨形成及矿化的影响。实验大鼠分为５组：对照组（Ｃ）；低剂量铝组（ＬＤＡ）；高剂量铝组（ＨＤＡ）；慢性肾功能不全组（ＣＲＦ）；慢性肾功能不全加高剂量铝组（ＣＲＦ—ＨＤＡ）；实验结果表明：ＬＤＡ、ＣＲＦ组与Ｃ组之间无明显差异（Ｐ＞０．０５）。ＨＤＡ及ＣＲＦ—ＨＤＡ组骨组织内四环素荧光双记线短、少，多为单标线，且粗细不一，增宽融合，表面有较多的类骨质沉积，尤以ＣＲＦ—ＨＤＡ组为甚。提示高剂量铝可影响大鼠骨基质明胶诱导性异位骨形成，阻碍其矿化作用，引起骨软化。尤其在慢性肾功能不全时，可加重此变化
The effects of different concentrations of aluminum on induced ectopic bone formation and mineralization during normal renal function and renal insufficiency were investigated by using non-decalcified bone biopsies combined with tetracycline double labeling and bone histomorphometry and aluminum staining. The experimental rats were divided into 5 groups: control group (C), low dose aluminum group (LDA), high dose aluminum group (HDA), chronic renal insufficiency group (CRF), chronic renal insufficiency plus high dose aluminum group -HDA). The experimental results showed that there was no significant difference between LDA, CRF and C (P> 0.05). In the HDA and CRF-HDA groups, the tetracycline double stained lines were shorter and fewer in the CRF-HDA group than in the CRF-HDA group very. Tip high-dose aluminum can affect rat bone matrix gelatin-induced ectopic bone formation, hinder its mineralization, causing osteomalacia. Especially in chronic renal insufficiency, this change can be exacerbated