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目的：观察犬单侧肺通气并左心转流前后通气侧与萎陷侧肺组织生化及病理形态的变化。方法：对８只犬建立单侧肺通气并左心转流模型，阻断降主动脉近、远端时间１０５±１６分，控制左心房压小于１．６０ｋＰａ（１２ｍｍＨｇ）。测定血浆凝血烷Ｂ２（血栓素Ｂ２，ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋ－ＰＧＦ１α）含量及肺组织血管紧张素转换酶活性、丙二醛含量、超氧化物歧化酶活性、组织病理形态等。结果：转流６０分左心房血浆ＴＸＢ２／６－ｋ－ＰＧＦ１α较前增高１９％（Ｐ＜０．０５）。转流后萎陷侧肺静脉血比值较前增高３５％（Ｐ＜０．０５），并明显高于通气侧肺静脉（Ｐ＜０．０５）；而通气侧较前无显著改变。转流后萎陷侧肺组织与转流前同侧肺和转流后通气侧肺比较，丙二醛含量升高，超氧化物歧化酶活性和血管紧张素转换酶活性降低。但双肺皆无明显形态学改变。结论：单肺通气并左心转流期间萎陷侧肺存在不伴有形态学改变的缺氧代谢。
OBJECTIVE: To observe the changes of biochemical and pathological features of lungs in ventilated and collapsed lungs before and after unilateral pulmonary ventilation and left heart bypass. Methods: A unilateral pulmonary ventilation and left ventricular circulation model was established in 8 dogs. The proximal and distal time of the descending aorta was occluded for 105 ± 16 minutes. The left atrial pressure was controlled to be less than 1.60 kPa (12 mmHg). The plasma levels of thromboxane B2 (TXB2), 6-keto-PGF1α (6-keto-PGF1α) and angiotensin-converting enzyme activity, MDA content and superoxide dismutase , Histopathology and so on. Results: The left atrial plasma TXB2 / 6-k-PGF1α increased by 19% (P <0.05) 60 minutes after the bypass. After bypass, the ratio of collapsed pulmonary veins increased 35% (P <0.05), and was significantly higher than that of ventilated side pulmonary veins (P <0.05). However, there was no significant change in ventilatory side compared with before. Compared with the ipsilateral lung before bypass and the ventilated side after bypass, the contents of MDA, SOD activity and angiotensin converting enzyme activity were decreased in the collapsed lung tissue. However, no obvious morphological changes in both lungs. CONCLUSION: There is hypoxia metabolism associated with morphological changes in collapsed lung during unilateral lung ventilation and left heart bypass.