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P53基因位于染色体17p13.1,是一种肿瘤抑制基因。已经发现,P53在多种人肿瘤中表现频繁的等位基因丧失与突变。卵巢癌是女性生殖系统中致死性最强的一种肿瘤。其发生的分子机理还不清楚。作者采用聚合酶链反应—单链构象多态性(PCR-SSCP)和RFLP分析,研究了31例手术的原
The P53 gene is located on chromosome 17p13.1 and is a tumor suppressor gene. It has been found that P53 exhibits frequent allelic loss and mutations in a variety of human tumors. Ovarian cancer is the most fatal cancer in the female reproductive system. The molecular mechanism of its occurrence is not yet clear. The authors used polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and RFLP analysis to study the original surgical procedures in 31 patients.