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目的:探讨替硝唑致过敏性休克的临床特点及规律,为临床合理使用替硝唑提供参考。方法:通过国内有关数据库检索替硝唑致过敏性休克的病例报告,下载原始病例资料,然后进行手工统计与分析。结果:国内期刊共报道替硝唑引起过敏性休克19例,其中口服给药9例,注射给药10例;男11例,女8例,年龄22-73岁,无死亡病例报告。替硝唑致过敏性休克的特点是:以速发型过敏性休克为主,无论是静脉滴注给药还是口服给药均是如此;12例患者在发生过敏性休克前有皮肤瘙痒和(或皮疹)的前驱症状,临床症状主要表现为循环系统和神经系统。结论:替硝唑引起的过敏性休克虽然没有导致死亡的严重后果,临床医务工作者同样应高度重视。
Objective: To investigate the clinical characteristics and rules of tinidazole-induced anaphylactic shock and to provide a reference for clinical use of tinidazole. Methods: A case report of tinidazole-induced anaphylactic shock was retrieved from the relevant domestic databases, and the original case data were downloaded and then manually analyzed and statistically analyzed. Results: Domestic journals reported 19 cases of tinidazole-induced anaphylactic shock, of which 9 cases were oral administration and 10 cases were administered by injection. There were 11 males and 8 females, aged 22-73 years, with no deaths reported. Tinidazole-induced anaphylactic shock is characterized by a rapid episode of anaphylactic shock, either intravenously or orally; in 12 patients with pruritus and / or Rash) of the prodromal symptoms, the main clinical manifestations of the circulatory system and the nervous system. CONCLUSION: Although tinidazole-induced anaphylactic shock has no serious consequences of death, clinicians should also attach great importance.