论文部分内容阅读
目的观察血清脂蛋白(α)[LP(α)]水平与冠心病(CHD)类型、病变和预后的关系。方法将CHD患者(95例)分为3组:急性心肌梗死(AMI)组30例,不稳定型心绞痛(UAP)组35例及稳定型心绞痛(SAP)组30例。取血测定LP(α)。对CHD患者在住院期间及出院1个月内进行观察,观察终点为主要急性心脏事件(MACE)。结果①当按CHD不同临床类型比较时,发现UAP与AMI组LP(α)水平与MACE发生率均显著高于SAP组(P<0.05或P<0.01),但UAP与AMI组差异未达到显著水平;②当按LP(α)水平分组比较时,≥300 mg/L组多支病变和MACE的发生率均显著高于LP(α)<300 mg/L组(均P<0.01)。结论LP(α)水平与CHD的严重程度有关,并与CHD预后相关。
Objective To investigate the relationship between the level of serum lipoprotein (α) [LP (α)] and the type, severity and prognosis of coronary heart disease (CHD). Methods Thirty CHD patients (95 cases) were divided into three groups: AMI group (30 cases), unstable angina pectoris group (UAP group) and stable angina pectoris group (SAP group). Blood was taken for determination of LP (α). CHD patients during hospitalization and discharged within 1 month were observed, the end point of the main acute cardiac events (MACE). Results ① When comparing different clinical types of CHD, LP (α) level and MACE incidence in UAP group and AMI group were significantly higher than those in SAP group (P <0.05 or P <0.01), but the differences between UAP group and AMI group did not reach significant (P <0.01) .2. When compared with group LP (α), the incidence of multi-vessel disease and MACE≥300 mg / L were significantly higher than those of LP (α) <300 mg / L. Conclusions The level of LP (α) is related to the severity of CHD and is related to the prognosis of CHD.