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本文对胃镜活检取得的115例胃或十二指肠粘膜组织,测定其匀浆液中的LDH同功酶。发现LDH-M相对值在萎缩性胃炎、肠化及胃癌粘膜中增高;随着肠化分化越成熟和分布程度越严重,其LDH-M越高,越接近于小肠粘膜内LDH-M;在萎缩性胃炎和肠化粘膜中,LDH同功酶重新定向倾向于“M”型,这种重新定向非常相似于胃癌粘膜组织,从而提示萎缩性胃炎及肠化与胃癌之间有着极为密切的关系。
In this paper, 115 cases of gastric or duodenal mucosal tissue obtained by gastroscope biopsy were measured for LDH isoenzyme in the homogenate. The relative values of LDH-M were found to increase in atrophic gastritis, intestinal metaplasia, and gastric mucosa. The more mature and more severe the distribution of LDH-M, the higher the LDH-M, the closer to LDH-M in the small intestine mucosa; In atrophic gastritis and intestinal mucosa, LDH isoenzymes tend to be redirected toward the “M” type. This reorientation is very similar to gastric mucosal tissue, suggesting that atrophic gastritis and intestinal metaplasia have a close relationship with gastric cancer. Relationship.