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目的:观察中期(4周)尾部悬吊大鼠在立位应激下的心血管反应。方法:采用本实验室改进的尾部悬吊方法,利用头高位倾斜和下体负压模拟立位应激,通过股动脉插管和心电图记录检测大鼠血压和心率改变。结果:与对照组相比,4周尾部悬吊(SUS)大鼠体重下降及后肢承重骨骼肌萎缩;其静息血压和心率与对照组(CON)相比无明显差别(P>0.05);在两组大鼠中,头高位倾斜和下体负压均可导致血压降低和心率加快,但SUS大鼠平均动脉压下降幅度与CON大鼠相比显著增大(P<0.05),而两组的心率增快幅度并无明显差别(P>0.05)。结论:4周尾部悬吊大鼠在立位应激下维持血压稳定的能力减弱,可用于中期失重/模拟失重后立位耐力不良机理的研究。
OBJECTIVE: To observe the cardiovascular response of mid-term (4 weeks) tail-suspended rats under standing stress. Methods: The tail suspension method modified by our laboratory was used to simulate vertical position stress by head tilt and lower body negative pressure. Blood pressure and heart rate were measured by femoral artery cannulation and electrocardiogram recording. Results: Compared with the control group, the weight and weight of the tail suspension (SUS) rats in 4 weeks were lower than those in the control group (P> 0.05). The resting blood pressure and heart rate were not significantly different from those in the control group (P> 0.05) In both groups, head tilt and lower body negative pressure both resulted in lower blood pressure and faster heart rate, but the decrease of mean arterial pressure in SUS rats was significantly higher than that in CON rats (P <0.05) Heart rate increased no significant difference (P> 0.05). CONCLUSION: The ability of tail suspension rats to maintain stable blood pressure under standing stress is weakened in 4 weeks, which can be used to study the mechanism of standing endurance dysfunction after medium-term weightlessness / simulated weightlessness.