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【目的】通过检测炎症因子白介素-5(IL-5)和嗜酸粒细胞趋化蛋白(eotaxin)的变化及临床表现,探讨孟鲁司特对呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎(毛支)后气道炎症的干预作用。【方法】选择88例初次喘息发作的具有特应性体质的患儿作为研究对象,随机选择40例毛支患儿作为对照组予常规治疗;48例观察组在常规治疗的同时口服孟鲁司特钠。分别在急性期及恢复期检测血清IL-5及eotaxin水平的变化,门诊随访3月,观察有无喘息再次发作。【结果】毛支患儿急性期血清IL-5及eotaxin水平明显增高,经孟鲁司特干预后,恢复期IL-5及eotaxin水平明显下降。3个月内喘息再次发作人数情况比较,观察组与对照组相比,差异具有统计学意义。【结论】孟鲁司特对RSV毛支患儿炎性因子IL-5和eotaxin有下调作用,可控制毛细支气管炎后的气道炎症,对毛支后喘息的反复发作具有预防作用。
【Objective】 To investigate the effect of montelukast on respiratory syncytial virus (RSV) capillary permeability by detecting the changes and clinical manifestations of interleukin-5 (IL-5) and eotaxin (inflammatory cytokines) Bronchitis (branch of hair) after the intervention of airway inflammation. 【Methods】 Eighty-eight children with atopic dermatitis who had first wheezing episodes were selected as study subjects and 40 cases of bronchiolitis were randomly chosen as the control group for routine treatment. Forty-eight cases were given routine treatment and montelukast Special sodium. Serum levels of IL-5 and eotaxin were detected in acute and convalescent phase respectively. Outpatients were followed up for 3 months to observe wheezing again. 【Results】 Serum levels of IL-5 and eotaxin were significantly increased in children with bronchiolitis and the levels of IL-5 and eotaxin in convalescent rats were significantly decreased after montelukast intervention. Compared with the control group, the difference between the observation group and the control group was statistically significant. 【Conclusion】 Montelukast can down-regulate the inflammatory factors IL-5 and eotaxin in children with RSV bronchiolitis, and can control the airway inflammation after bronchiolitis and prevent the repeated episodes of wheezing and wheezing.