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目的:探讨急性脑梗塞患者外周血内皮祖细胞(Circulating endothelial progenitor cells,CEPCs)数目变化情况。方法:回顾性分析40例急性脑梗塞患者的临床资料(研究组),采用流式细胞仪检测患者的CEPCs数目,并与同期40例健康体检患者(对照组)进行比较。结果:研究组CEPCs数目明显低于对照组,差异具有统计学意义(P<0.05)。结论:高血压、高血糖与高血脂是急性脑梗塞三大危险因素,CEPCs数目与脑出血危险因素呈负相关,通过测定患者的CEPCs数目,可评估脑血管功能和预测潜在脑血管风险。
Objective: To investigate the changes of the number of peripheral blood progenitor cells (CEPCs) in patients with acute cerebral infarction. Methods: The clinical data of 40 patients with acute cerebral infarction (study group) were retrospectively analyzed. The number of CEPCs in patients with acute cerebral infarction was analyzed by flow cytometry and compared with 40 healthy subjects (control group) in the same period. Results: The number of CEPCs in the study group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). CONCLUSION: Hypertension, hyperglycemia and hyperlipidemia are the three risk factors of acute cerebral infarction. The number of CEPCs is negatively correlated with the risk factors of cerebral hemorrhage. The number of CEPCs in patients can be assessed for cerebrovascular function and potential cerebrovascular risk.