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目的 采用食饵性兔动脉粥样硬化 (AS)为模型 ,探讨辛伐他汀对食饵性兔AS形成过程中血浆内皮素 (ET)、血清一氧化氮 (NO)的作用。方法 雄性新西兰兔 4 2只 (1 92 4± 0 175kg) ,随机分为正常对照组、AS模型组和辛伐他汀组。在实验前、造模第 8、12周末分别测定ET、NO及主动脉AS面积。结果 在AS形成的中期和晚期 ,辛伐他汀组主动脉AS面积及ET均显著低于AS模型组 (P <0 0 1) ;实验第 12周末辛伐他汀组及AS模型组NO均低于正常对照组 (P <0 0 5～ 0 0 1) ,且辛伐他汀组NO与AS模型组无显著差异 (P >0 0 5 )。结论 辛伐他汀能阻抑AS时ET的升高 ,此特性可能与其抗AS作用有关
Objective To investigate the effect of simvastatin on plasma endothelin (ET) and serum nitric oxide (NO) during the formation of diet-induced AS in rabbits by using rabbit model of atherosclerosis (AS). Methods Forty two male New Zealand rabbits (1 92 4 ± 0 175 kg) were randomly divided into normal control group, AS model group and simvastatin group. Before the experiment, at the end of the 8th and 12th week of modeling, the area of ET, NO and aorta were measured respectively. Results The AS area and ET in simvastatin group were significantly lower than those in AS model group (P <0.01) in the middle and late stages of AS formation. The NO in Simvastatin group and AS model group at the end of 12th week was lower than that in AS model group The normal control group (P <0.05-0.01), and there was no significant difference between simvastatin group and AS model group (P> 0.05). Conclusion Simvastatin can inhibit the elevation of ET in ET, which may be related to the anti-AS effect