心血管疾病、糖尿病、肿瘤等人类罹患的最普遍的慢性病，都是多因素疾病，这些疾病的发生发展是由多个危险因素共同作用的结果。炎症是这些系统性疾病的共同病理机制，任何造成或增强机体炎症状态的因素都可能成为这些系统性疾病的危险因素。牙周炎症过程中，无论是进入血液循环中的牙周致病菌和细菌组分（如细菌脂多糖）激发宿主的免疫炎症反应、产生一系列炎症因子，还是牙周病变组织局部产生的这些炎症因子进入血液循环，都可增强机体系统性的炎症状态，成为一系列以炎症为病理机制的系统性疾病的危险因素。“,”The common chronic disorders in the world, such as cardiovascular diseases, diabetes mellitus, cancers, etc., are all the multi-factorial diseases. They are caused by the interactions of various risk factors among which inflammation plays an important role in the pathogenesis of all these chronic disorders. Any factor which contributes or enhances systemic inflammatory burdens may serve as the risk factors of these diseases. During periodontitis, the bacteremia and subsequent systemic dispersal of periodontal pathogens and bacterial components may elicit production of pro-inflammatory immune mediators, and the pro-inflammatory immune mediators produced locally at the periodontal lesion may also enter the systemic circulation. Behaving as a potential source for increased chronic systemic inflammatory challenge, periodontitis contributes as the risk factor of these systemic inflammation associated chronic diseases.