眼镜蛇神经毒素(NT)在小鼠热板及大鼠电尾嘶叫测痛模型,都显示出明显的镇痛作用,并有剂量-效应关系。注射NT 0.022mg/kg,2h后,大鼠痛阈出现显著上升,3h后达到较佳效果,并能保持其效应强度达24h。连续给小鼠注射NT 0.023mg/kg,持续9d,小鼠并不产生耐受现象。结果提示,NT的镇痛机理可能与吗啡不同。 Cobra neurotoxin (NT) in the mouse hot plate and rat tail twitching pain model, showed a significant analgesic effect, and a dose-response relationship. After injection of NT 0.022mg / kg, the pain threshold of rats increased significantly after 2 hours and reached the best effect after 3 hours, and the effect intensity was maintained for 24 hours. Mice were injected with NT 0.023 mg / kg continuously for 9 days, and mice did not develop tolerance. The results suggest that the analgesic mechanism of NT may be different with morphine.