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目的 评价放射治疗合并光动力疗法对中晚期食管癌的临床长期疗效。方法 1991年 10月至 1992年 12月 ,60例中晚期食管鳞癌被随机分为两组。对照组 :3 0例 ,常规体外放射治疗DT60 -66Gy/6-7周 ;综合组 3 0例 ,体外放射治疗同对照组 ,当DT40Gy/4周时加用光动力疗法 (PDT)。血卟啉衍生物 (HpD)按 5mg/Kg的剂量静脉滴注 ,48h、72h后在胃镜直视下对食管病变部位分段各行一次光照。波长为 63 0nm的红光 ,输出功率 40 0～ 5 0 0mW /cm2 ,每段光照时间 15min。结果 全部病人随访满 10年 ,60例中失访 3例 ,随访率 95 0 %。对照组和综合组 5年生存率分别为 16 7%、2 9 9%,10年生存率分别为 10 0 %、16 7%差异有显著意义(P <0 0 5 )。结论 放射治疗加光动力疗法优于单纯放射治疗 ,可明显提高中晚期食管癌的长期生存率
Objective To evaluate the long-term effect of radiotherapy combined with photodynamic therapy on advanced esophageal cancer. Methods From October 1991 to December 1992, 60 cases of advanced esophageal squamous cell carcinoma were randomly divided into two groups. Control group: 30 cases of conventional external beam radiotherapy DT60 -66Gy / 6-7 weeks; 30 cases of combination group, in vitro radiotherapy with the control group, when DT40Gy / 4 weeks plus photodynamic therapy (PDT). Hematoporphyrin derivative (HpD) according to the dose of 5mg / Kg intravenous infusion, 48h, 72h after esophageal lesion under the direct vision of gastroscopic segment of each row of a light. Wavelength of 63 0nm red light, the output power of 40 0 ~ 500mW / cm2, each light time 15min. Results All patients were followed up for 10 years, 3 cases were lost in 60 cases and the follow-up rate was 95%. The 5-year survival rates of the control group and the comprehensive group were 16.7% and 29.9%, respectively. The 10-year survival rates were 100% and 167% respectively (P <0.05). Conclusion Radiotherapy and photodynamic therapy is superior to radiotherapy alone, and can significantly improve the long-term survival rate of advanced esophageal cancer