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作者将73例肝硬化合并严重感染(大多数为自发性腹膜炎和菌血症)患者随机分为两组:第一组36例应用氨苄青霉素+妥布霉素治疗,第二组37例用头孢氨噻肟(Cefotaxine)治疗,比较两组的疗效及肾毒性。两组病人在临床资料、肝肾功能试验、感染类型和分离的细菌等方面均相似。氨苄青剂量按内生肌酐廓清率调整,如GFR>80ml/min,则用2.0g静滴q4h;妥布剂量为1.75mg/kg静滴q8h;头孢氨噻肟用量同氨苄青。除非初次血培养的细菌
The authors randomized 73 patients with cirrhosis and severe infections (mostly spontaneous peritonitis and bacteremia) to two groups: 36 in the first group treated with ampicillin + tobramycin, 37 in the second group Cefotaxine treatment, efficacy and nephrotoxicity were compared between the two groups. The two groups of patients were similar in clinical data, liver and kidney function tests, types of infection, and isolated bacteria. Ampicillin dose adjusted according to endogenous creatinine clearance rate, such as GFR> 80ml / min, then use 2.0g intravenous infusion q4h; TuBu dose of 1.75mg / kg intravenous infusion q8h; cefotaxime consumption with the same ampicillin. Unless the initial blood culture of bacteria