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目的:探讨米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床效果。方法:选取2008年11月～2011年11月期间在我院门诊部接受治疗的围绝经期功能失调性子宫出血的患者78例,随机将所有患者分为研究组和对照组各39例,对照组,给予米非司酮片进行治疗。研究组在服用米非司酮的基础上加服妈富隆片进行治疗。结果:治疗后,对照组的总有效率为89.7%,研究组的总有效率为97.4%,两组差异显著,具有统计学意义(P<0.05)。治疗组控制出血时间和完全止血时间均低于对照组,差异显著,具有统计学意义(P<0.05)。治疗后,研究组子宫内膜为(4.12±0.35)mm,对照组为(6.70±0.68)mm,两组比较差异显著,具有统计学意义(P<0.05)。讨论:米非司酮联合妈富隆比单纯用药的控制出血时间和完全止血时间更短,临床疗效更加显著,且安全可靠,是治疗围绝经期子宫出血的首选方案。
Objective: To investigate the clinical effect of mifepristone and marvelon in treating peri-menopausal dysfunctional uterine bleeding. Methods: Seventy-eight patients with peri-menopausal dysfunctional uterine bleeding were treated in our outpatient department from November 2008 to November 2011. All patients were randomly divided into study group (39 cases) and control group (39 cases) Group, given mifepristone tablets for treatment. The study group took mifepristone on the basis of plus service Fu Fulong tablets for treatment. Results: After treatment, the total effective rate of the control group was 89.7%, and the total effective rate of the study group was 97.4%. There was significant difference between the two groups (P <0.05). The bleeding time and complete hemostasis time of the treatment group were lower than the control group, the difference was significant, with statistical significance (P <0.05). After treatment, the endometrial thickness was (4.12 ± 0.35) mm in the study group and (6.70 ± 0.68) mm in the control group, with significant difference between the two groups (P <0.05). Discussion: mifepristone combined with Marvelon than the simple control of bleeding time and complete bleeding time shorter, more significant clinical efficacy, and safe and reliable, is the treatment of perimenopausal uterine bleeding the preferred program.