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日本骨髓移植的开展始于1975年,由金泽大学的服部教授和名古屋大学的上田教授等人研究进行。但是,最初的效果并不理想,其病例数也极少。直到1980年治疗效果才有所提高,病例数也不断增加,截至1985年10月,日本厚生省骨髓移植研究班共统计314例。在骨髓移植患者中,急性白血病最多,共193例;再生障碍性贫血45例;慢性髓性白血病36例。其中176例死亡,主要死因是间质性肺炎,占30%;其次是白血病复发,占22%;细菌感染症占15.9%;GVHD 占6.3%。
Japanese bone marrow transplantation began in 1975, by the Kenso University Kanazawa University professor and professor of Ueno study. However, the initial effect was not satisfactory and the number of cases was very small. Until 1980 the treatment effect was increased, the number of cases also continued to increase, as of October 1985, Japan Ministry of Health Bone marrow transplantation classes a total of 314 cases of statistics. In bone marrow transplant patients, the most acute leukemia, a total of 193 cases; 45 cases of aplastic anemia; 36 cases of chronic myeloid leukemia. Among them, 176 died, the main cause of death was interstitial pneumonia, accounting for 30%; followed by leukemia recurrence, accounting for 22%; bacterial infection accounted for 15.9%; GVHD accounted for 6.3%.