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胸腺是T淋巴细胞分化和功能上成熟的微环境。T淋巴细胞干细胞由骨髓进入胸腺后,在胸腺内发育和进一步分化,成为功能上不同的T细胞亚群,然后输入到外周淋巴器官(脾脏、淋巴结)和血液内。胸腺细胞在发育过程中,细胞表面抗原发生一系列的明显变化,待细胞分化成熟后,功能不同的细胞呈现不同的表面抗原。测定细胞表面抗原能够反映出细胞分化的不同阶段或细胞的不同功能亚群。小鼠的淋巴细胞干细胞在分化为胸腺细胞的开始阶段就获得了TL(T淋巴细胞表面抗原)、Thy-1(θ抗原)和Ly1,2,3表面抗原。随着进一步发育,胸腺细胞变为TL~-,Thy抗原减少和H_2抗原(组织相容性抗原)增加。同
Thymus is T lymphocyte differentiation and functionally mature microenvironment. T lymphocyte stem cells enter the thymus from the bone marrow, develop and further differentiate in the thymus and become functionally distinct subsets of T cells, which are then transduced into peripheral lymphoid organs (spleen, lymph nodes) and blood. During the development of thymus cells, a series of significant changes occur on the cell surface antigens. After cells differentiate and mature, different functional cells present different surface antigens. Determination of cell surface antigen can reflect the different stages of cell differentiation or different functional subpopulations of cells. Lymphocyte stem cells from mice acquire TL (T lymphocyte surface antigen), Thy-1 (θ antigen), and Ly1,2,3 surface antigen at the initial stage of differentiation into thymocytes. As further development, thymus cells become TL ~ -, Thy antigen decreased and H 2 antigen (histocompatibility antigen) increased. with