论文部分内容阅读
目的探讨MCH联合脐血高浓度Hb溶液电泳对新生儿α-地中海贫血检出结果的影响。方法针对2012年1月至2014年12月来我院进行分娩的2160例新生儿分别进行MCH辅助脐血高浓度和低浓度Hb溶液电泳检查,观察两种检查在新生儿α-地中海贫血中检出结果差异。结果本研究2160例新生儿经诊断金标准确诊新生儿α-地中海贫血患者201例。MCH联合脐血高浓度Hb溶液电泳检查的假阳性率、假阴性率、阴性似然比均低于MCH联合脐血低浓度Hb溶液电泳检查,而灵敏度、特异度、阳性似然比、阳性预测值、阴性预测值及诊断正确率均高于MCH联合脐血低浓度Hb溶液电泳检查,尤其在静止型α-地中海贫血中检出率明显优于低浓度Hb溶液电泳检查,分别经卡方检验,差异均有统计学意义(P﹤0.05);而两组检查的阳性率、阴性率均无统计学差异(P>0.05)。结论 MCH联合脐血高浓度Hb溶液电泳在新生儿α-地中海贫血的检查中具有较高的诊断准确性,尤其在静止型α-地中海贫血中最佳。
Objective To investigate the effect of MCH combined with high concentration Hb solution of cord blood on the detection of α-thalassemia in neonates. Methods A total of 2160 newborn infants who came to our hospital from January 2012 to December 2014 were respectively examined by MCH-assisted high-concentration cord blood and low-concentration Hb solution electrophoresis. The two tests were examined in neonatal α-thalassemia Differences in the results. Results 201 cases of newborn infants with 201 cases of α-thalassemia were confirmed by diagnostic gold standard. The false positive rate, false negative rate and negative likelihood ratio of MCH combined with cord blood Hb solution electrophoresis were lower than that of MCH combined with low concentration Hb solution of cord blood, while the sensitivity, specificity, positive likelihood ratio, positive predictive value Value, negative predictive value and diagnostic accuracy were higher than MCH combined with low concentration of cord blood Hb solution electrophoresis examination, especially in the stationary α-thalassemia detection rate was significantly better than low concentration Hb solution electrophoresis, respectively, by chi-square test (P <0.05). There was no significant difference between the two groups in the positive rate and the negative rate (P> 0.05). Conclusion MCH combined with cord blood Hb solution electrophoresis has high diagnostic accuracy in the detection of α-thalassemia of newborns, especially in resting α-thalassemia.