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目的探讨丙种球蛋白及干扰素在脑炎患儿中的临床疗效。方法收集2013年4月至2016年8月濮阳市油田总医院儿科收治的98例病毒性脑炎患儿,根据治疗药物的不同随机分为实验组和对照组,对照组患儿在基础治疗上给予丙种球蛋白治疗,实验组患儿在基础治疗上应用丙种球蛋白联合干扰素治疗,观察比较两组患儿临床治疗效果和临床症状差异。结果实验组总有效率为95.92%,明显高于对照组的73.47%,发热、抽搐、呕吐、意识障碍症状消失时间与对照组比较显著缩短,差异具有统计学意义(P<0.05)。结论病毒性脑炎患儿采用丙种球蛋白及干扰素治疗可显著提高治疗效果,改善临床症状,临床值得推广应用。
Objective To investigate the clinical efficacy of gamma globulin and interferon in children with encephalitis. Methods A total of 98 children with viral encephalitis admitted in Puyang Oilfield General Hospital from April 2013 to August 2016 were randomly divided into experimental group and control group according to the different therapeutic drugs. Given gamma globulin treatment, experimental group of children in the basic treatment of gamma globulin combined with interferon treatment, observation and treatment of children in both groups clinical efficacy and clinical symptoms were compared. Results The total effective rate in the experimental group was 95.92%, which was significantly higher than that in the control group (73.47%). The disappearance time of fever, convulsion, vomiting and disturbance of consciousness were significantly shorter than those in the control group (P <0.05). Conclusion Children with viral encephalitis treated with gamma globulin and interferon can significantly improve the therapeutic effect and improve the clinical symptoms, which is worth popularizing and clinical application.